Positive regulation of peptidyl-serine phosphorylation

Across TCGA cell cohorts, RNA activity of the Positive regulation of peptidyl-serine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DRAM1, PRR14, and TBC1D5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DRAM1 grouped by Positive regulation of peptidyl-serine phosphorylation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DRAM1 →	-0.797	-0.638	.004	.001	3	5
SOFT_TISSUE	PRR14 →	-0.850	-1.201	.001	.001	3	5
BREAST	TBC1D5 →	-1.009	-1.092	.003	<.001	3	4
BREAST	SLC9B2 →	-1.321	-0.892	.002	.005	3	4
SOFT_TISSUE	CFAP97 →	-0.982	-1.906	.002	<.001	3	4
BREAST	KBTBD6 →	-0.615	-0.872	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DRAM1 by Positive regulation of peptidyl-serine phosphorylation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →