Negative regulation of peptidyl-serine phosphorylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of peptidyl-serine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HBA2, HBA1, and SYNPO2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of peptidyl-serine phosphorylation activity versus HBA2 in OV (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HBA2 →	+1.462	+0.544	.004	.006	3	5
BRCA	HBA1 →	+0.996	+0.205	.005	<.001	3	5
GBM	SYNPO2 →	+0.878	+0.257	.001	<.001	3	5
BRCA	CENPA →	-1.251	-0.223	<.001	.001	3	4
LUAD	HBB →	+1.596	+0.205	<.001	<.001	2	5
BRCA	PKMYT1 →	-0.842	-0.212	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033137 vs HBA2 — OV

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