Positive regulation of RNA splicing

Across TCGA patient cohorts, RNA activity of the Positive regulation of RNA splicing pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBM12B_S839, PHRF1_S915, and HDGFL2_S366, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of RNA splicing activity versus RBM12B_S839 in GBM (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RBM12B_S839 →	+0.619	+0.272	<.001	<.001	3	6
UCEC	PHRF1_S915 →	+0.459	+0.280	<.001	<.001	3	6
OV	HDGFL2_S366 →	+1.761	+0.305	.003	<.001	3	6
COAD	SRRT_S74 →	+0.622	+0.170	<.001	<.001	3	5
COAD	SUDS3_S45 →	+0.781	+0.283	.007	.001	3	5
BRCA	ZC3H18_T677 →	+0.486	+0.202	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033120 vs RBM12B_S839 — GBM

Explore this scatter interactively →