Negative regulation of RNA splicing

Across TCGA cell cohorts, RNA activity of the Negative regulation of RNA splicing pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SART1, PIMREG, and PIP4P1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of RNA splicing activity versus SART1 in OESOPHAGUS (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SART1 →	+1.069	+0.198	.004	.004	3	5
BLOOD_Leukemia	PIMREG →	+1.907	+0.108	.001	.004	3	4
LUNG_SCLC	PIP4P1 →	+0.599	+0.098	.002	.003	3	4
BLOOD_Leukemia	LILRB3 →	+0.394	+0.115	.002	.003	3	4
CNS	CNTROB →	+0.667	+0.149	.004	<.001	2	5
BREAST	MRGBP →	+0.660	+0.113	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033119 vs SART1 — OESOPHAGUS

Explore this scatter interactively →