Mitochondrial respiratory chain complex assembly

Across TCGA patient cohorts, RNA activity of the Mitochondrial respiratory chain complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELK3, CHSY1, and ZNF281, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial respiratory chain complex assembly activity versus ELK3 in BRCA (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ELK3 →	-0.593	-0.170	<.001	.007	3	6
COAD	CHSY1 →	-0.471	-0.206	<.001	<.001	3	6
COAD	ZNF281 →	-0.398	-0.219	.002	.003	3	6
BRCA	RAB8B →	-0.523	-0.178	<.001	<.001	3	6
LSCC	ST3GAL6 →	-0.525	-0.161	.001	.004	3	6
BRCA	PALM2AKAP2 →	-0.693	-0.235	<.001	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033108 vs ELK3 — BRCA

Explore this scatter interactively →