Positive regulation of T cell differentiation in thymus

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell differentiation in thymus pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LSP1_S252, SIPA1_S839, and SASH3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell differentiation in thymus activity versus LSP1_S252 in PDAC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LSP1_S252 →	+0.782	+0.073	<.001	.002	3	10
UCEC	SIPA1_S839 →	+0.474	+0.067	<.001	<.001	3	9
OV	SASH3 →	+0.534	+0.096	<.001	<.001	3	9
LSCC	SEPTIN1 →	+0.798	+0.083	<.001	<.001	3	9
GBM	TNFAIP8 →	+0.560	+0.083	<.001	<.001	3	9
BRCA	STK4 →	+0.344	+0.055	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033089 vs LSP1_S252 — PDAC

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