Negative regulation of T cell differentiation in thymus

Across TCGA patient cohorts, RNA activity of the Negative regulation of T cell differentiation in thymus pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MTMR9, ADNP_S876, and VSIR_S235, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell differentiation in thymus activity versus MTMR9 in LUAD (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTMR9 →	-0.121	-0.051	.007	.006	3	4
COAD	ADNP_S876 →	+0.694	+0.154	.008	.002	3	4
UCEC	VSIR_S235 →	-0.453	-0.067	.006	.005	3	4
UCEC	KMT2C_S4304 →	+0.354	+0.087	.005	<.001	3	4
BRCA	GPRIN3 →	-0.374	-0.062	.008	.003	3	4
OV	DPYSL3 →	+0.506	+0.071	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033085 vs MTMR9 — LUAD

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