Negative regulation of T cell differentiation in thymus

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of T cell differentiation in thymus pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in kidney chromophobe (KICH), where higher Negative regulation of T cell differentiation in thymus pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as CHOL and LUSC, show the opposite pattern, with higher activity associated with better survival.

KICH, ACC, and CHOL are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	II,III,IV	0.569	0.913	.007	41	view →
ACC	DFS	Median	All	0.170	0.661	<.001	34	view →
CHOL	DFS	Quartile	All	0.770	0.218	.005	24	view →
SKCM	OS	Quartile	II,III,IV	0.656	0.918	<.001	19	view →
LUSC	OS	Tertile	III,IV	0.718	0.426	.008	15	view →
HNSC	DFS	Tertile	All	0.548	0.683	.011	13	view →
TGCT	DFS	Tertile	All	0.520	0.720	.010	12	view →
LAML	DFS	Median	All	0.267	0.484	.017	12	view →
READ	DFS	Tertile	IV	0.377	0.712	.025	12	view →
MESO	OS	Quartile	II,III,IV	0.476	0.266	.021	12	view →
COAD	DFS	Median	III,IV	0.455	0.714	.017	9	view →
LUAD	DFS	Quartile	All	0.859	0.765	.015	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0033085–KICH (DFS)

Open the KICH breakdown →