Negative regulation of T cell differentiation in thymus

Across TCGA patient cohorts, RNA activity of the Negative regulation of T cell differentiation in thymus pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERBB2, TXNDC15, and GRB7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell differentiation in thymus activity versus ERBB2 in BRCA (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ERBB2 →	+1.716	+0.763	<.001	.001	3	5
UCEC	TXNDC15 →	-0.347	-0.617	.008	.002	3	4
BRCA	GRB7 →	+1.747	+0.841	<.001	<.001	3	4
GBM	ZNF25 →	-0.566	-0.406	<.001	.001	3	4
UCEC	COMMD4P2 →	+0.340	+0.719	.004	.005	3	4
UCEC	KIZ →	-0.909	-0.857	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033085 vs ERBB2 — BRCA

Explore this scatter interactively →