Negative regulation of T cell differentiation in thymus

Across TCGA cell cohorts, RNA activity of the Negative regulation of T cell differentiation in thymus pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAGAP, RP9, and KCNAB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAGAP grouped by Negative regulation of T cell differentiation in thymus-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TAGAP →	-0.803	-1.774	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	RP9 →	-0.839	-1.326	.007	.006	3	4
BONE	KCNAB1 →	-0.300	-1.552	.005	.003	3	4
KIDNEY	ACOT13 →	+1.267	+1.707	.003	<.001	3	3
KIDNEY	STK32C →	+0.684	+1.149	.004	.001	3	3
OESOPHAGUS	ALG3 →	+1.027	+1.454	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAGAP by Negative regulation of T cell differentiation in thymus activity — URINARY_TRACT

Explore this box plot interactively →