Negative regulation of T cell differentiation in thymus

Across TCGA cell cohorts, RNA activity of the Negative regulation of T cell differentiation in thymus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN2A, MTSS1, and BORCS7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell differentiation in thymus activity versus CDKN2A in BLOOD_Leukemia (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CDKN2A →	+6.326	+2.409	.004	<.001	2	4
BLOOD_Leukemia	MTSS1 →	+3.957	+1.961	.006	.008	3	3
BREAST	BORCS7 →	-1.449	-1.669	.009	<.001	3	3
LUNG_SCLC	SLC22A18 →	-2.140	-1.142	.002	<.001	3	3
LUNG_SCLC	RTN1 →	+2.575	+1.344	.001	.007	3	3
LUNG_SCLC	OSGIN1 →	-1.820	-0.936	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033085 vs CDKN2A — BLOOD_Leukemia

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