Immature T cell proliferation

pathway activity — cross-omics
GO:0033079Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Immature T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C14orf93, IFI27L2, and CCS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMC14orf93 →-0.384-0.459<.001.00434
CCRCCIFI27L2 →-0.414-0.273<.001.00434
CCRCCCCS →-0.382-0.474<.001.00634
GBMOSER1-DT →-0.349-0.649.002<.00134
CCRCCALDH3A2 →-0.710-0.499.002.00534
GBMLRIG2 →-0.403-0.668<.001.00234
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration