Cellular pigmentation

Across TCGA patient cohorts, RNA activity of the Cellular pigmentation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBL, FMO5, and NDC80, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular pigmentation activity versus FBL in BRCA (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FBL →	-0.911	-0.642	<.001	<.001	3	6
BRCA	FMO5 →	+1.785	+0.642	<.001	<.001	3	5
UCEC	NDC80 →	-0.831	-0.366	.001	.001	3	5
PDAC	SHROOM3 →	+0.872	+0.599	<.001	.002	3	5
BRCA	CAPN8 →	+2.109	+0.530	<.001	<.001	3	5
PDAC	SHROOM3-AS1 →	+0.653	+0.586	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033059 vs FBL — BRCA

Explore this scatter interactively →