Regulation of chromosome organization

Across TCGA patient cohorts, RNA activity of the Regulation of chromosome organization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, CENPF_S3079, and HAT1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chromosome organization activity versus SMC2 in UCEC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMC2 →	+0.815	+0.108	<.001	<.001	3	10
LUAD	CENPF_S3079 →	+1.179	+0.069	<.001	<.001	3	10
GBM	HAT1 →	+0.440	+0.062	<.001	<.001	3	10
HNSC	RFC2 →	+0.488	+0.092	<.001	<.001	3	9
LUAD	RRM2 →	+1.018	+0.073	<.001	<.001	3	9
LUAD	SMC4 →	+0.706	+0.073	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033044 vs SMC2 — UCEC

Explore this scatter interactively →