Negative regulation of myeloid cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of myeloid cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA11, IL32, and KCNRG, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of myeloid cell apoptotic process activity versus ANXA11 in OVARY (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ANXA11 →	-1.265	-0.170	<.001	<.001	3	6
BLOOD_Lymphoma	IL32 →	-5.153	-0.170	.002	<.001	3	4
BLOOD_Leukemia	KCNRG →	+0.545	+0.150	.003	.001	3	4
STOMACH	AAGAB →	-0.759	-0.196	.002	.004	3	4
BONE	MAP2K6 →	+2.803	+0.311	<.001	.004	3	4
STOMACH	TMEM139 →	-2.742	-0.194	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033033 vs ANXA11 — OVARY

Explore this scatter interactively →