Tetrapyrrole catabolic process

Across TCGA patient cohorts, RNA activity of the Tetrapyrrole catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM97, TOP2A, and MIR223HG, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrapyrrole catabolic process activity versus TMEM97 in GBM (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TMEM97 →	-0.714	-0.243	<.001	<.001	3	6
LSCC	TOP2A →	-0.965	-0.237	<.001	<.001	3	5
GBM	MIR223HG →	+0.946	+0.185	<.001	<.001	3	5
LSCC	NDC1 →	-0.593	-0.248	<.001	<.001	3	5
CCRCC	HES1 →	-0.631	-0.113	.002	.006	3	5
GBM	PRDM11 →	-0.452	-0.161	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033015 vs TMEM97 — GBM

Explore this scatter interactively →