Tetrapyrrole metabolic process

Across TCGA cell cohorts, RNA activity of the Tetrapyrrole metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMIM14, TAPBPL, and C11orf16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrapyrrole metabolic process activity versus SMIM14 in BREAST (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SMIM14 →	+1.621	+0.287	.002	<.001	3	5
PANCREAS	TAPBPL →	+1.368	+0.246	.002	.001	3	5
URINARY_TRACT	C11orf16 →	+0.069	+0.309	<.001	.004	3	4
OESOPHAGUS	PSIP1 →	-1.112	-0.166	.004	.002	3	4
OESOPHAGUS	MOB1B →	-0.945	-0.231	.002	<.001	3	4
LARGE_INTESTINE	MRFAP1 →	-0.517	-0.172	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033013 vs SMIM14 — BREAST

Explore this scatter interactively →