Positive regulation of mast cell activation

Across TCGA patient cohorts, RNA activity of the Positive regulation of mast cell activation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HK3, PTPRJ, and TXNL4A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mast cell activation activity versus HK3 in GBM (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HK3 →	+0.922	+0.081	<.001	<.001	3	6
PDAC	PTPRJ →	+0.354	+0.052	<.001	<.001	3	6
GBM	TXNL4A →	-0.147	-0.056	<.001	<.001	3	6
LSCC	PRAM1_S484 →	+0.824	+0.073	<.001	<.001	3	6
PDAC	C5AR1_S327 →	+0.889	+0.054	.005	.002	3	5
LSCC	ARRB2 →	+0.274	+0.078	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033005 vs HK3 — GBM

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