Positive regulation of mast cell activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of mast cell activation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED8, RPS8, and EIF4G2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMED8 grouped by Positive regulation of mast cell activation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TMED8 →	-0.940	-2.084	<.001	<.001	3	4
LIVER	RPS8 →	+0.660	+1.668	<.001	<.001	3	4
BONE	EIF4G2 →	-0.867	-1.608	.002	.001	3	4
OESOPHAGUS	FBXO30 →	-0.670	-0.826	.001	.004	3	4
BREAST	VTI1A →	-0.569	-1.250	.001	<.001	3	4
LARGE_INTESTINE	HMGA1 →	-0.751	-0.981	.008	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMED8 by Positive regulation of mast cell activation activity — URINARY_TRACT

Explore this box plot interactively →