Positive regulation of mast cell activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of mast cell activation pathway is significantly associated with the drug response of multiple features, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Methotrexate, N24798-49-A1, and Phenformin, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Methotrexate grouped by Positive regulation of mast cell activation-low versus -high activity in KIDNEY.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Methotrexate →	+0.432	+1.163	.007	.026	3	1
KIDNEY	N24798-49-A1 →	+0.080	+0.680	.036	.044	3	1
KIDNEY	Phenformin →	-0.780	-0.660	.042	.031	3	1
KIDNEY	WEHI-539 →	+0.942	+1.163	.005	.026	3	1
KIDNEY	Venotoclax →	+0.217	+1.163	.049	.026	3	1
KIDNEY	Staurosporine →	+1.915	+1.994	.024	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Methotrexate by Positive regulation of mast cell activation activity — KIDNEY

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