Negative regulation of mast cell activation

Across TCGA patient cohorts, RNA activity of the Negative regulation of mast cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP152, CDCA7L, and C1QL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mast cell activation activity versus CEP152 in BRCA (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CEP152 →	-0.344	-0.473	.007	.007	3	4
BRCA	CDCA7L →	-0.802	-0.729	<.001	<.001	3	4
GBM	C1QL3 →	+0.954	+0.352	<.001	.005	3	3
BRCA	CIT →	-0.391	-0.554	.004	.002	3	3
LSCC	TPGS2 →	-0.435	-0.565	.001	<.001	3	3
BRCA	RCC1 →	-0.338	-0.501	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033004 vs CEP152 — BRCA

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