Muscle cell proliferation

Across TCGA patient cohorts, RNA activity of the Muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIX1L, PTGS2, and RNF180, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell proliferation activity versus LIX1L in BRCA (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LIX1L →	+0.829	+0.159	<.001	.002	3	2
BRCA	PTGS2 →	+0.837	+0.180	.004	<.001	3	2
OV	RNF180 →	+1.110	+0.194	.004	.006	3	2
OV	NFKBID →	+0.810	+0.159	.008	.003	3	2
OV	DUS1L →	-0.451	-0.141	.007	.001	3	2
OV	MRPS16 →	-0.876	-0.167	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033002 vs LIX1L — BRCA

Explore this scatter interactively →