Muscle cell proliferation

Across TCGA pan-cancer cohorts, RNA activity of the Muscle cell proliferation pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 233 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Muscle cell proliferation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and CHOL, show the opposite pattern, with higher activity associated with better survival.

LGG, HNSC, and CHOL are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Tertile	All	0.380	0.569	<.001	36	view →
HNSC	DFS	Tertile	III,IV	0.695	0.505	.001	32	view →
CHOL	DFS	Tertile	All	0.901	0.177	<.001	30	view →
THCA	OS	Quartile	III,IV	0.912	1.000	.003	27	view →
SKCM	OS	Median	All	0.405	0.270	.001	26	view →
KIRP	DFS	Quartile	All	0.506	0.791	.002	24	view →
STAD	DFS	Quartile	All	0.356	0.548	.009	19	view →
KIRC	DFS	Tertile	IV	0.744	0.478	.025	18	view →
COAD	DFS	Tertile	All	0.704	0.798	.009	15	view →
UCEC	DFS	Tertile	IV	0.973	0.579	.022	10	view →
ESCA	OS	Median	III,IV	0.574	0.335	.021	9	view →
LIHC	DFS	Median	III,IV	0.587	0.241	.030	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0033002–LGG (OS)

Open the LGG breakdown →