Muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IAH1, ZFP1, and CCDC107, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IAH1 grouped by Muscle cell proliferation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	IAH1 →	-0.941	-1.377	<.001	.001	3	3
BLOOD_Lymphoma	ZFP1 →	-1.063	-2.173	.005	.006	3	3
BLOOD_Leukemia	CCDC107 →	+0.698	+0.352	.006	.004	3	3
BLOOD_Leukemia	MAGEF1 →	+1.246	+0.538	.001	.004	3	3
CNS	RAB1A →	-0.450	-0.693	<.001	.004	3	3
KIDNEY	BIRC3 →	-1.479	-0.913	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IAH1 by Muscle cell proliferation activity — KIDNEY

Explore this box plot interactively →