Muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Muscle cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are POLDIP2, IMP3, and TFG, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell proliferation activity versus POLDIP2 in PANCREAS (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	POLDIP2 →	+1.153	+1.306	.001	<.001	2	16
LUNG_SCLC	IMP3 →	+1.140	+1.079	<.001	.001	3	12
OVARY	TFG →	-1.464	-0.962	<.001	.001	3	11
BREAST	KRR1 →	+0.760	+0.901	.002	.005	3	11
OVARY	NOP56 →	+0.917	+1.080	<.001	<.001	3	10
CNS	EBNA1BP2 →	+0.786	+0.871	.007	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033002 vs POLDIP2 — PANCREAS

Explore this scatter interactively →