Protein-DNA complex disassembly

Across TCGA patient cohorts, RNA activity of the Protein-DNA complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX17, YLPM1, and MED13L, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-DNA complex disassembly activity versus DDX17 in ACC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	DDX17 →	+0.965	+0.057	<.001	<.001	3	34
SCLC	YLPM1 →	+0.914	+0.119	<.001	<.001	3	34
DLBC	MED13L →	+1.230	+0.072	<.001	<.001	3	34
KICH	EMSY →	+0.750	+0.043	.001	<.001	3	34
THYM	BPTF →	+1.092	+0.055	<.001	<.001	3	34
DLBC	ZBTB40 →	+1.475	+0.095	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032986 vs DDX17 — ACC

Explore this scatter interactively →