Protein-DNA complex disassembly

Across TCGA patient cohorts, RNA activity of the Protein-DNA complex disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM28, DDX47, and SMARCA4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-DNA complex disassembly activity versus TRIM28 in OV (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TRIM28 →	+0.312	+0.051	.008	.006	3	9
LSCC	DDX47 →	+0.280	+0.046	<.001	<.001	3	7
LSCC	SMARCA4 →	+0.313	+0.045	.001	<.001	3	7
GBM	SF3B3 →	+0.292	+0.059	<.001	<.001	3	6
GBM	TOM1L2 →	-0.227	-0.030	.001	.003	3	6
GBM	AKAP8L →	+0.285	+0.044	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032986 vs TRIM28 — OV

Explore this scatter interactively →