Protein-DNA complex disassembly

Across TCGA cell cohorts, RNA activity of the Protein-DNA complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB18, TFAP4, and EEF1G, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-DNA complex disassembly activity versus RAB18 in LIVER (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RAB18 →	-1.028	-0.300	.004	.001	3	6
SOFT_TISSUE	TFAP4 →	+1.080	+0.314	.008	<.001	2	7
BLOOD_Lymphoma	EEF1G →	+0.616	+0.214	.006	.001	3	5
SKIN	ATAD3A →	+0.661	+0.142	.005	.008	3	5
KIDNEY	HMGA1 →	+2.637	+0.260	.001	.005	3	5
CNS	RAB5IF →	-0.580	-0.238	.007	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032986 vs RAB18 — LIVER

Explore this scatter interactively →