Positive regulation of transcription elongation by RNA polymerase II

Across TCGA patient cohorts, RNA activity of the Positive regulation of transcription elongation by RNA polymerase II pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOP2A, ESCO2, and PARPBP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription elongation by RNA polymerase II activity versus TOP2A in LUAD (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A →	+0.953	+0.252	<.001	<.001	3	8
COAD	ESCO2 →	+0.789	+1.243	<.001	.004	3	7
UCEC	PARPBP →	+0.742	+0.304	<.001	<.001	3	7
UCEC	DEPDC1 →	+0.881	+0.285	<.001	<.001	3	7
LSCC	RFC5 →	+0.865	+0.406	<.001	<.001	3	7
LUAD	HROB →	+0.683	+0.233	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032968 vs TOP2A — LUAD

Explore this scatter interactively →