Regulation of inositol trisphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of inositol trisphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC42EP4, PDXP, and MRPL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC42EP4 grouped by Regulation of inositol trisphosphate biosynthetic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CDC42EP4 →	-2.345	-1.570	.004	.009	3	4
KIDNEY	PDXP →	+0.901	+1.254	.006	.001	3	4
CNS	MRPL2 →	+0.416	+0.766	.002	.007	2	5
LUNG_NSCLC_LUAD	CHKA →	+0.566	+0.714	.004	<.001	3	4
PANCREAS	NDST1 →	+1.399	+1.137	.004	.001	3	4
STOMACH	HLCS →	-0.841	-1.351	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC42EP4 by Regulation of inositol trisphosphate biosynthetic process activity — BLOOD_Lymphoma

Explore this box plot interactively →