Secretion by tissue

Across TCGA patient cohorts, RNA activity of the Secretion by tissue pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCAS1, WIZ, and BRMS1L_S197, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Secretion by tissue activity versus BCAS1 in LUAD (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BCAS1 →	+1.315	+0.051	<.001	<.001	3	7
GBM	WIZ →	-0.291	-0.043	.003	.004	3	6
GBM	BRMS1L_S197 →	-0.489	-0.049	.003	.001	3	6
LSCC	ANO1 →	+0.942	+0.054	<.001	.002	3	6
LSCC	DUT_S99 →	-0.895	-0.064	<.001	<.001	3	5
GBM	SUPT16H →	-0.389	-0.048	.009	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032941 vs BCAS1 — LUAD

Explore this scatter interactively →