Positive regulation of superoxide anion generation

Across TCGA cell cohorts, RNA activity of the Positive regulation of superoxide anion generation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCA, EXOSC2, and PIF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FANCA grouped by Positive regulation of superoxide anion generation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FANCA →	+0.823	+0.839	.001	.001	3	6
BREAST	EXOSC2 →	+0.753	+0.900	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PIF1 →	+1.704	+1.260	.006	.002	3	5
UPPER_AERODIGESTIVE_TRACT	DNAJB7 →	+0.133	+1.174	.002	.007	3	5
BLOOD_Leukemia	RIN1 →	-1.580	-0.786	.001	.005	3	5
OVARY	NUP205 →	+0.805	+1.224	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FANCA by Positive regulation of superoxide anion generation activity — BREAST

Explore this box plot interactively →