Positive regulation of activin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of activin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP39, ZNF696, and HSPA8P3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of activin receptor signaling pathway activity versus ARHGAP39 in BRCA (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGAP39 →	+0.574	+0.600	.002	<.001	3	3
OV	ZNF696 →	+0.525	+0.632	<.001	.002	3	3
LSCC	HSPA8P3 →	+0.454	+0.475	<.001	.002	3	3
LSCC	HGH1 →	+0.412	+0.442	.003	.005	3	3
LSCC	IFITM3P5 →	+0.419	+0.418	.004	.009	3	3
BRCA	SCLY →	+0.177	+0.607	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032927 vs ARHGAP39 — BRCA

Explore this scatter interactively →