Regulation of activin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of activin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are URI1, LIN37, and DMGDH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of activin receptor signaling pathway activity versus URI1 in OESOPHAGUS (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	URI1 →	-0.993	-0.239	<.001	.004	3	4
CNS	LIN37 →	-0.455	-0.211	.004	.005	3	4
BLOOD_Lymphoma	DMGDH →	-1.432	-0.163	.004	.007	2	5
LUNG_NSCLC_LUAD	NOP56 →	+0.646	+0.161	.004	.008	2	5
LUNG_SCLC	GOSR2 →	-0.667	-0.348	.002	.002	3	4
LUNG_NSCLC_LUSC	PARD3B →	-1.650	-0.478	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032925 vs URI1 — OESOPHAGUS

Explore this scatter interactively →