Positive regulation of transforming growth factor beta1 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of transforming growth factor beta1 production pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM273, CCL2, and CRISPLD2, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transforming growth factor beta1 production activity versus TMEM273 in SCLC (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	TMEM273 →	+1.332	+0.174	<.001	<.001	3	28
SCLC	CCL2 →	+1.511	+0.165	<.001	<.001	3	27
UCS	CRISPLD2 →	+1.792	+0.086	.001	.004	2	28
CHOL	MMP19 →	+1.596	+0.123	<.001	.002	2	28
ACC	THBS1 →	+2.209	+0.089	<.001	<.001	2	28
ACC	ICAM1 →	+1.867	+0.077	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032914 vs TMEM273 — SCLC

Explore this scatter interactively →