Positive regulation of transforming growth factor beta1 production

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of transforming growth factor beta1 production pathway differs between tumor and matched normal tissue in 14 of the 18 cancer types tested.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRP and KICH, show the opposite pattern, with lower activity in tumor tissue.

KIRP, KICH, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRP	Male	II,III,IV	−0.164	<.001	11	view →
KICH	Female	II,III,IV	−0.238	<.001	10	view →
LUSC	Male	III,IV	−0.155	<.001	8	view →
STAD	All	II,III,IV	+0.084	.001	8	view →
KIRC	Male	All	−0.069	<.001	8	view →
COAD	Female	All	+0.064	<.001	7	view →
BRCA	All	III,IV	−0.157	<.001	6	view →
UCEC	All	II,III,IV	−0.096	<.001	6	view →
THCA	All	IV	+0.102	<.001	5	view →
BLCA	All	All	−0.076	.006	5	view →
LIHC	Male	All	−0.075	<.001	5	view →
HNSC	Female	All	+0.070	.011	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 14 lineages.

GO:0032914–KIRP

Open the KIRP breakdown →