Positive regulation of transforming growth factor beta1 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of transforming growth factor beta1 production pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDK12_S423, MED1_S1401, and CPSF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transforming growth factor beta1 production activity versus CDK12_S423 in HNSC (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CDK12_S423 →	-0.301	-0.084	<.001	.002	3	6
LSCC	MED1_S1401 →	-0.559	-0.103	<.001	<.001	3	6
LSCC	CPSF1 →	-0.212	-0.088	<.001	<.001	3	6
GBM	EXOSC7 →	-0.245	-0.125	.002	.005	3	6
LSCC	FKBP4 →	-0.392	-0.092	<.001	<.001	3	6
GBM	PARP4_S1722 →	+0.816	+0.136	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032914 vs CDK12_S423 — HNSC

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