Positive regulation of transforming growth factor beta1 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of transforming growth factor beta1 production pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP7, HNRNPH3, and SBNO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MMP7 grouped by Positive regulation of transforming growth factor beta1 production-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MMP7 →	+2.188	+0.654	.007	.004	3	4
BONE	HNRNPH3 →	-0.407	-0.358	.001	.008	3	4
LARGE_INTESTINE	SBNO1 →	-0.666	-0.989	<.001	.001	3	3
LARGE_INTESTINE	MS4A1 →	-0.360	-1.023	.002	<.001	3	3
SKIN	SLC25A33 →	-0.443	-0.648	.003	.001	3	3
BLOOD_Leukemia	KIAA1549 →	-0.802	-0.821	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MMP7 by Positive regulation of transforming growth factor beta1 production activity — BREAST

Explore this box plot interactively →