Positive regulation of transforming growth factor beta1 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of transforming growth factor beta1 production pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PER2, PXK, and VSX2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PER2 grouped by Positive regulation of transforming growth factor beta1 production-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PER2 →	+0.112	+0.183	<.001	<.001	3	4
SKIN	PXK →	+0.134	+0.153	.007	.002	3	4
LUNG_NSCLC_LUSC	VSX2 →	-0.306	-0.252	.005	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	BATF3 →	-0.174	-0.217	.006	.008	3	4
CNS	STYXL1 →	+0.119	+0.232	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	COL10A1 →	-0.144	-0.334	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PER2 by Positive regulation of transforming growth factor beta1 production activity — SKIN

Explore this box plot interactively →