Positive regulation of transforming growth factor beta1 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of transforming growth factor beta1 production pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THBS1, ATP6AP2, and TIMP1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transforming growth factor beta1 production activity versus THBS1 in LIVER (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	THBS1 →	+4.877	+0.275	<.001	.008	2	14
BONE	ATP6AP2 →	+1.183	+0.273	<.001	<.001	3	11
SOFT_TISSUE	TIMP1 →	+2.501	+0.238	<.001	<.001	3	10
BONE	IL6ST →	+2.652	+0.351	<.001	<.001	3	10
LIVER	FLNA →	+2.427	+0.290	<.001	<.001	3	10
LUNG_NSCLC_LUSC	NRP1 →	+3.324	+0.306	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032914 vs THBS1 — LIVER

Explore this scatter interactively →