Positive regulation of transforming growth factor beta1 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of transforming growth factor beta1 production pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRTC1, ARPC1B, and SLC25A21, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transforming growth factor beta1 production activity versus CRTC1 in LUNG_NSCLC_LUAD (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CRTC1 →	-0.718	-1.132	.002	.007	3	2
LUNG_NSCLC_LUAD	ARPC1B →	-1.492	-1.183	.001	.004	3	2
LUNG_NSCLC_LUAD	SLC25A21 →	-1.899	-1.759	<.001	<.001	3	2
LUNG_NSCLC_LUAD	FAM214A →	-2.446	-1.659	.006	<.001	3	2
BREAST	PPP1R37 →	+1.774	+0.587	.006	<.001	3	2
LUNG_NSCLC_LUAD	STBD1 →	-0.991	-1.183	.008	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032914 vs CRTC1 — LUNG_NSCLC_LUAD

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