Negative regulation of transforming growth factor beta1 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of transforming growth factor beta1 production pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGF9, FOXO3B, and ZNF286B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transforming growth factor beta1 production activity versus FGF9 in OV (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FGF9 →	-1.163	-0.846	.002	<.001	3	4
GBM	FOXO3B →	-0.584	-0.809	<.001	<.001	3	4
OV	ZNF286B →	-0.670	-0.969	<.001	<.001	3	4
LSCC	WWC2-AS2 →	+0.210	+0.552	.003	.003	3	4
BRCA	SPIN2B →	-0.365	-0.535	.002	<.001	3	3
GBM	SOBP →	-0.494	-0.497	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032911 vs FGF9 — OV

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