Regulation of transforming growth factor beta1 production

Across TCGA cell cohorts, RNA activity of the Regulation of transforming growth factor beta1 production pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGTR2, NCOR1, and CASK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGTR2 grouped by Regulation of transforming growth factor beta1 production-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AGTR2 →	-0.174	-0.237	.002	.003	3	5
BLOOD_Leukemia	NCOR1 →	+0.364	+0.222	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	CASK →	+0.172	+0.248	.001	.009	3	4
BLOOD_Leukemia	ABHD14A →	+0.176	+0.279	.003	.001	3	4
LUNG_NSCLC_LUAD	GMEB1 →	-0.145	-0.174	<.001	.003	3	4
LUNG_SCLC	CD6 →	-0.154	-0.205	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGTR2 by Regulation of transforming growth factor beta1 production activity — BLOOD_Leukemia

Explore this box plot interactively →