Transforming growth factor beta2 production

pathway activity — cross-omics
GO:0032906Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Transforming growth factor beta2 production pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GRPEL1, RAB11FIP2_S277, and PXDN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVGRPEL1 →-0.392-0.062<.001<.00135
PDACRAB11FIP2_S277 →+0.333+0.054.004.00435
BRCAPXDN →+0.528+0.079<.001<.00135
GBMSLC39A10 →+0.293+0.107.001<.00135
UCECRIN2_S366 →+0.346+0.064.001.00334
OVSLC9A3R1 →-0.498-0.071.003<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration