Transforming growth factor beta1 production

Across TCGA cell cohorts, RNA activity of the Transforming growth factor beta1 production pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYRK4, INTS2, and PPP3CA, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transforming growth factor beta1 production activity versus DYRK4 in CNS (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DYRK4 →	-0.825	-1.718	.008	.001	3	2
CNS	INTS2 →	-0.608	-1.415	.001	.003	3	2
CNS	PPP3CA →	-0.984	-1.724	.001	.001	3	2
CNS	DNAH3 →	-0.063	-1.518	.008	.007	2	3
CNS	COG1 →	-0.483	-1.524	.003	.002	3	2
CNS	CFAP99 →	-0.128	-1.401	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032905 vs DYRK4 — CNS

Explore this scatter interactively →