Negative regulation of viral transcription

Across TCGA patient cohorts, RNA activity of the Negative regulation of viral transcription pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM13, ELK4, and PAN3, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of viral transcription activity versus TRIM13 in UVM (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	TRIM13 →	+0.821	+0.042	<.001	<.001	3	32
DLBC	ELK4 →	+1.198	+0.075	<.001	.004	3	31
DLBC	PAN3 →	+0.804	+0.049	<.001	<.001	3	31
KICH	SCYL3 →	+0.672	+0.033	<.001	<.001	3	31
UVM	INTS6 →	+0.921	+0.040	<.001	<.001	3	30
DLBC	FNBP4 →	+0.940	+0.043	<.001	.003	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032897 vs TRIM13 — UVM

Explore this scatter interactively →