Negative regulation of viral transcription

Across TCGA patient cohorts, RNA activity of the Negative regulation of viral transcription pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_S368, RRBP1_T275, and RPL5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of viral transcription activity versus RFC1_S368 in BRCA (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RFC1_S368 →	-0.523	-0.025	.005	.007	3	6
HNSC	RRBP1_T275 →	-0.346	-0.051	.004	.008	3	6
BRCA	RPL5 →	-0.155	-0.037	<.001	<.001	3	6
BRCA	TTI1 →	-0.263	-0.033	<.001	<.001	3	5
LUAD	CLK3_S157 →	-0.272	-0.035	.004	.002	3	5
CCRCC	SEPTIN8 →	+0.420	+0.049	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032897 vs RFC1_S368 — BRCA

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