Negative regulation of viral transcription

Across TCGA patient cohorts, RNA activity of the Negative regulation of viral transcription pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC4D, C6orf118, and TREML2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of viral transcription activity versus CLEC4D in GBM (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CLEC4D →	+0.381	+0.106	.001	.001	3	4
UCEC	C6orf118 →	+1.165	+0.313	<.001	<.001	3	3
GBM	TREML2 →	+0.437	+0.133	.001	<.001	3	3
GBM	FCAR →	+0.655	+0.117	.002	<.001	3	3
BRCA	HLA-DRA →	+0.489	+0.367	.003	.009	3	3
LSCC	RPS27P14 →	-0.207	-0.453	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032897 vs CLEC4D — GBM

Explore this scatter interactively →