Positive regulation of organic acid transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of organic acid transport pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF2, ARL17B, and RHEBL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IRF2 grouped by Positive regulation of organic acid transport-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IRF2 →	+0.968	+1.251	.003	.008	3	4
CNS	ARL17B →	+0.701	+0.981	.002	.009	2	5
BLOOD_Leukemia	RHEBL1 →	+1.467	+1.013	.009	.006	3	4
PANCREAS	MRPL15 →	+0.618	+0.713	.004	.006	3	3
PANCREAS	GRIPAP1 →	-1.046	-1.073	.002	.009	3	3
STOMACH	ZNF711 →	+1.950	+1.073	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IRF2 by Positive regulation of organic acid transport activity — SOFT_TISSUE

Explore this box plot interactively →