Positive regulation of organic acid transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of organic acid transport pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMF, TFAP2A, and DOCK5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of organic acid transport activity versus BMF in SOFT_TISSUE (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	BMF →	-2.797	-0.381	<.001	<.001	3	5
LUNG_SCLC	TFAP2A →	+2.033	+0.165	.003	.005	3	5
BLOOD_Lymphoma	DOCK5 →	+2.255	+0.211	<.001	<.001	3	5
LUNG_NSCLC_LUSC	CAPG →	+5.250	+0.312	<.001	<.001	3	5
LUNG_NSCLC_LUAD	PLCD3 →	+1.241	+0.188	.003	.001	3	5
LIVER	MYOF →	+4.107	+0.274	.008	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032892 vs BMF — SOFT_TISSUE

Explore this scatter interactively →